Researchers from King’s College London have identified a previously overlooked mechanism that may explain how brain cells die in Alzheimer’s disease and frontotemporal dementia. The study found that toxic protein buildup can trigger a process called karyoptosis, causing the cell’s nucleus to shrink and break apart, ultimately leading to neuron death. Researchers also identified a key molecular pathway involved in this process, offering a potential new target for future treatments. The findings could help scientists develop therapies that slow the loss of brain cells, potentially delaying disease progression and preserving cognitive function for longer.
